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Aldehyde and Ketone Reactions – Hydrates, Acetals, & Imines: Crash Course Organic Chemistry #29


We’ve already learned the basics of carbonyl chemistry and talked about how we can synthesize aldehydes and ketones, but there’s still so much more to learn, like the role carbonyl groups play in reactions involving sedatives! In this episode of Crash Course Organic Chemistry we’re diving deeper into aldehydes and ketones by focusing on addition reactions of oxygen and nitrogen based nucleophiles. We’ll cover hydrates, acetals and hemiacetals, imines and enamines, and more!

Episode Sources:
io9. 2020. This Is The Drug In The Rolling Stones’ Song “Mother’s Little Helper”. [online] Available at: https://io9.gizmodo.com/this-is-the-drug-in-the-rolling-stones-song-mothers-li-1693032181
Bionity.com. 2020. Mickey_Finn_(Drugs). [online] Available at: https://www.bionity.com/en/encyclopedia/Mickey_Finn_%28drugs%29.html#The_Chicago_bartender_Michael_.22Mickey.22_Finn
Chm.bris.ac.uk. 2020. Ninhydrin – Molecule Of The Month – April 2018. [online] Available at: http://www.chm.bris.ac.uk/motm/ninhydrin/ninhydrinh.htm
Ewan, H.S., Iyer, K., Hyun, S.H., Wleklinski, M., Cooks, R.G. and Thompson, D.H., 2017. Multistep flow synthesis of diazepam guided by droplet-accelerated reaction screening with mechanistic insights from rapid mass spectrometry analysis. Organic Process Research & Development, 21(10), pp.1566-1570.

Series Sources:
Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.
Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.
Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.
Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014.
Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.
Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.
McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.
Smith, J. G., Organic chemistry; 6th ed.; McGraw-Hill Education, New York, 2020.
Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.

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